Functional organization of chromosomes in the mammalian cell nucleus
Imperial College London –
Chromosomes are not randomly folded in a spaguetti-like state in the mammalian cell nucleus, as initially thought, but occupy distinct territories. Recent studies show that these chromosome territories have preferential arrangements in different cell types, which correlate with the kinds of chromosome rearrangements that occur preferentially in each cell type. Evidence for a growing number of long-range interactions between DNA segments in the same or different chromosomes has raised the possibility of a three-dimensional network of genome interactions. As the long-range interactions described so far correlate with gene activity states, they are likely to influence and be influenced by the transcriptome of each cell type. We propose that this interchromosomal network of interactions contains epigenetic information and determines cell-type specific chromosome conformations and re-arrangements.
Date: 2006-Nov-27 Time: 14:00:00 Room: Anfiteatro FA1 – IST
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Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.