Biochemical neutral solutions using S-system models
University of Texas M.D.Anderson Cancer Center –
One of the major difficulties of modeling biological systems from time series is the identification of a parameter set which gives the model the same dynamical behavior of the data. A more austere goal is the identification of the biochemical interaction of the systems components from the model parameters. In this talk, we present a method for the S-System parameter space identification from biological time series based on Monte Carlo process and a parameter optimization algorithm. The proposed methodology was applied to real time series data from the glycolytic pathway of the bacteria Lactococcus latis and ensembles of models with different network topologies were generated. The parameter optimization algorithm was also successfully applied to the same dynamical data however imposing a pre-specified network topology from previous knowledge, foreseeing the method as an exploration tool for test of hypothesis and design of new experiments.
Date: 2008-Dec-03 Time: 15:00:00 Room: 04
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Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.