Estimating Local Ancestry in Admixed Populations
International Computer Science Institute (ICSI) –
Large-scale genotyping of SNPs has shown a great promise in identifying
markers that could be linked to diseases.
One of the major obstacles involved in performing these studies is that
the underlying population sub-structure could produce spurious associations.
Population sub-structure can be caused by the presence of two distinct
sub-populations or a single pool of admixed individuals. In this talk, I
will focus on the latter which is significantly harder to detect in practice.
New advances in this research direction are expected to play a key role in identifying loci which are different among different populations and are still associated with a disease. Furthermore, the detection of an individual ancestry has important medical implications. I will describe two methods that we have recently developed to detect admixture, or the locus-specific ancestry in an admixed population. We have run extensive experiments to characterize the important parameters that have to be optimized when considering this problem – I will describe the results of thes experiments in context with existing tools such as SABER and STRUCTURE.
Date: 2009-Jan-29 Time: 11:00:00 Room: 336
For more information:
Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.