Estimating Local Ancestry in Admixed Populations
International Computer Science Institute (ICSI) –
Large-scale genotyping of SNPs has shown a great promise in identifying
markers that could be linked to diseases.
One of the major obstacles involved in performing these studies is that
the underlying population sub-structure could produce spurious associations.
Population sub-structure can be caused by the presence of two distinct
sub-populations or a single pool of admixed individuals. In this talk, I
will focus on the latter which is significantly harder to detect in practice.
New advances in this research direction are expected to play a key role in identifying loci which are different among different populations and are still associated with a disease. Furthermore, the detection of an individual ancestry has important medical implications. I will describe two methods that we have recently developed to detect admixture, or the locus-specific ancestry in an admixed population. We have run extensive experiments to characterize the important parameters that have to be optimized when considering this problem – I will describe the results of thes experiments in context with existing tools such as SABER and STRUCTURE.
Date: 2009-Jan-29 Time: 11:00:00 Room: 336
For more information:
INESC-ID ESR Talks – February 2023
If you are a masters/PhD student or a postdoctoral fellow, come and present your work in an informal and friendly environment – and savour some tasty snacks!
Individual talks will be 10-15 minutes plus time for feedback. Enroll on your selected date by emailing pedro.ferreira[at]inesc-id.pt.
Happening on the second Wednesday of every month (4pm-5pm):
- 15 February (Alves Redol, Room 9)
- 15 March (Alves Redol, Room 9)
- 12 April (Alves Redol, Room 9)
- 10 May (Alves Redol, Room 9)
- 14 June (Alves Redol, Room 9)
- 12 July (Alves Redol, Room 9)
We hope to see you there!