Human Immunodeficiency Virus (HIV) Dynamic Modeling and Antiretroviral Treatment Analysis
Ana Calhau, Constança Roquette, Teresa Cordeiro,
Instituto Superior Técnico –
Abstract:
The emergence of the Acquired Immune Deficiency Syndrome (AIDS) raised new problems and concerns worldwide. HIV-AIDS is now a global disease which has great influence in people’s lives, especially in developing countries and controlling this type of disease has a significant socio-economical impact.
HIV virus attacks preferentially CD4+ T immune cells, incorporating its DNA, which was previously transcript from a viral RNA, into the cells’ genome. Antiretroviral treatments act in different stages of HIV’s infection, decreasing the organism’s viral loads. The simplest dynamic models for HIV’s infection behavior relate the concentrations of healthy and infected CD4+T cells with viral load. Currently there are more complex models which compare more state variables and parameters.
For a better knowledge of the disease it is essential to cross information obtained through these mathematical models with data from infected people.
The goal of this project is to understand HIV’s complexity and to explore its dynamic, through a mathematical model based on nonlinear differential equations. Biomedical Engineering is expected to have a crucial role in the development of new tools and techniques for discovering a potential AIDS cure.
Date: 2010-Mar-26 Time: 14:00:00 Room: 336
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Upcoming Events
INESC Brussels HUB Winter Meeting 2023

This edition of the HUB Winter Meeting will be co-organised with Science Business and will take place on the 30 and 31 January, in Lisbon, at Instituto Superior Técnico, Department of Computer Science and Engineering.
Please see below a summary of the agenda, this will be updated on the INESC Brussels HUB website regularly (confirmed speakers and other relevant info). Places for onsite participation are limited so registration is mandatory. Online participants will be sent a ZOOM link for each specific session on the 27th January.
INESC Brussels HUB website: https://hub.inesc.pt/
Monday, 30 January
a) Digital Europe Programme & Chips Act: state of play and possibilities for INESC.
9h to 10h30 GMT
(Exclusive for INESC researchers and administrators).
b) Science Business: how can INESC tap into Science Business network, activities and communications tools.
(Exclusive for INESC researchers and administrators).
c) Networking Lunch (for all onsite participants).
d) Roundtable: From rhetoric to reality – Embedding international strategy in the DNA of research organisations.
(Closed-door, roundtable workshop, Chatham House rules, open to INESC researchers and administrators, external participants by invitation only).
e) Networking Dinner
(By invitation only – INESC researchers participating onsite in the event are elegible to join).
Tuesday, 31 January
f) Workshop: How they did it? Strategic positioning for structural success in Horizon Europe: a discussion of best practices.
(Exclusive for INESC researchers, administrators and international invited speakers).
g) The public consultation on European R&I Programmes: Towards FP10.
(Closed-door, roundtable workshop, Chatham House rules, open to INESC researchers and administrators, external participants by invitation only).
h) Networking Lunch (for all onsite participants).
i) Management Committee meeting (Directors and POB members)
The HUB Winter Meeting aims at bringing together researchers and administrators from the 5 INESC institutes, affiliated higher education institutions in Portugal and abroad, with key European and global players, to:
– Discuss key research and innovation issues at EU level.
– Inform institutional policy and strategy.
– Exchange best-practices about R&I management, career development and policy positioning.
– Promote, discuss and deliver vision, visibility, networking and impactful communication.
– Create, identify and deepen partnerships and collaboration opportunities for collaborative R&I.