Dynamic model identification of Lactococcus lactis metabolism time-series
Systems Biology is an emerging field within bioscience, that uses holism, a global and integrative perpective rather than a reductinism to explain the biological system´s behavior. This approach is particularly useful to quantitatively characterize and predict the systems dynamic. In our application multivariate time-series of Lactococcus lactis metabolite concentrations are measured in perturbation experiments. Prior knowledge about the metabolic network topology is represented in the form of parametrized nonlinear ordinary differential equations. Our goal is to identify appropriate models and parameters to the network.
In this talk two different approaches will be introduced for parameter estimation: Bayesian filtering and unified modeling of Glucose uptake. We concluded that Bayesian approach offers powerful tools for identifying parameters of such networks if the identifiability is granted. Taking several different experiments in account may results model parameters that can describe the systems behavior in various conditions.
Date: 2010-Oct-15 Time: 14:00:00 Room: 336
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Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.