José B. Pereira-Leal
Instituto Gulbenkian da Ciência –
Eukaryotic cells have a complex organization into membrane-delimited organelles. Whereas we have been steadily accumulating mechanistic data on the organization and regulation of these compartments, far less is understood about their origins and evolution. I will discuss our recent work in the evolutionary analysis of three types of intracellular compartments: endosymbiotic, endomembranous, and microtube-derived. To study evolution at a this level we are having to develop new sets of tools, from neutral models at the whole genome evolution level, sequence classification methods, ways to link molecular information with morphology and databases. I will discuss how we are using these tools to discover new principles and new molecular components. Unexpectedly, this evolutionary approach is leading us to new ways of finding drugable targets and to reposition existing drugs.
Date: 2010-Dec-07 Time: 12:30:00 Room: Room C01 – IST (Pavilhão Central)
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Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.