Towards a mathematical model of risk assessment of biocide induced antibiotic resistance
INESC-ID Lisboa and IST –
Biocides have been widely used for several decades to preserve materials including food and cosmetics, to decontaminate surfaces, to disinfect instruments, used in fabrics and, even, in toys, for personal hygiene, and to prevent transmission of infections. Nevertheless, when used in large volumes or at high concentrations, biocides have toxic effects and excessive use is dangerous for the environment, including animals and humans. Despite this widespread and ever increasing use of biocides, most bacterial and fungal species remain susceptible but decreased susceptibility has been reported and occasionally linked to antibiotic resistance, mainly in human and veterinary pathogens.
The problem of the development of resistances, together with the possibility to prevent them, has been carefully considered by the EC in the Biocides Directive 98/8/CE, a norm which oversees a high protection for the environment and man, and harmonizes the rules for placing on the market within the European Union any active substances and biocidal products.
This work is developed in the context of the European project BIOHYPO (Proposal No 227258 of the Programme “FP7 Cooperation Work Programme: Food, Agriculture and Fisheries, and Biotechnologies’) (Dr. Marco Oggioni, PI). The main goal is the evaluation of the risk for clinically significant increase or spread of antibiotic resistance in food pathogens due to biocide use. Statistical analyses are performed in a large data set of Staphylococcus aureus in order to have insight about the real clinical relevance of any antibiotic/biocide co- and cross-resistance.
Date: 2011-Jul-08 Time: 15:00:00 Room: Anf. Qa1.2 – Torre Sul (IST)
For more information:
Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.