Host-pathogen interaction upon infection with Listeria using NGS techniques
Joana Cruz,
Departamento de Engenharia Informática –
Abstract:
Listeria monocytogenes is a model bacterial pathogen whose, after internalization, is
capable of disrupting a double-membrane vacuole, replicate in the host cytosol and
manipulate the innate response triggered in the cytosol. Its intracellular lifecycle in the
human host provides insight into the dynamics of general host-pathogen
interactions. The identification of host sequences affected during these interactions is
paramount to our understanding of how pathogens engineer their cellular
environments.
The main goal of this project is, therefore, to comprehend in which way pathogens are
influencing human host cells, by identifying global changes in the host transcriptome
and characterizing the alterations in host nuclear architecture. Furthermore, it is aimed
to associate these changes to different stages of the Listeria monocytogenes infection
lifecycle. For that, total RNA was extracted from three different cell populations at four
time-points (after 20, 60, 120 and 240 minutes) with the purpose of having represented
specific stages in the bacterium lifecycle.
Date: 2013-Jun-07 Time: 11:00:00 Room: 336
For more information:
- http://kdbio.inesc-id.pt/cms/
- lsr@kdbio.inesc-id.pt
- (+351) 21 31 00272
Upcoming Events
INESC Brussels HUB Winter Meeting 2023

This edition of the HUB Winter Meeting will be co-organised with Science Business and will take place on the 30 and 31 January, in Lisbon, at Instituto Superior Técnico, Department of Computer Science and Engineering.
Please see below a summary of the agenda, this will be updated on the INESC Brussels HUB website regularly (confirmed speakers and other relevant info). Places for onsite participation are limited so registration is mandatory. Online participants will be sent a ZOOM link for each specific session on the 27th January.
INESC Brussels HUB website: https://hub.inesc.pt/
Monday, 30 January
a) Digital Europe Programme & Chips Act: state of play and possibilities for INESC.
9h to 10h30 GMT
(Exclusive for INESC researchers and administrators).
b) Science Business: how can INESC tap into Science Business network, activities and communications tools.
(Exclusive for INESC researchers and administrators).
c) Networking Lunch (for all onsite participants).
d) Roundtable: From rhetoric to reality – Embedding international strategy in the DNA of research organisations.
(Closed-door, roundtable workshop, Chatham House rules, open to INESC researchers and administrators, external participants by invitation only).
e) Networking Dinner
(By invitation only – INESC researchers participating onsite in the event are elegible to join).
Tuesday, 31 January
f) Workshop: How they did it? Strategic positioning for structural success in Horizon Europe: a discussion of best practices.
(Exclusive for INESC researchers, administrators and international invited speakers).
g) The public consultation on European R&I Programmes: Towards FP10.
(Closed-door, roundtable workshop, Chatham House rules, open to INESC researchers and administrators, external participants by invitation only).
h) Networking Lunch (for all onsite participants).
i) Management Committee meeting (Directors and POB members)
The HUB Winter Meeting aims at bringing together researchers and administrators from the 5 INESC institutes, affiliated higher education institutions in Portugal and abroad, with key European and global players, to:
– Discuss key research and innovation issues at EU level.
– Inform institutional policy and strategy.
– Exchange best-practices about R&I management, career development and policy positioning.
– Promote, discuss and deliver vision, visibility, networking and impactful communication.
– Create, identify and deepen partnerships and collaboration opportunities for collaborative R&I.