Integrative biomarker discovery in neurodegenerative diseases: a survey
INESC-ID Lisboa and IST –
Data mining has been widely applied in biomarker discovery, resulting in
significant findings of different clinical and biological biomarkers. With
developments in technology, from genomics to proteomics analysis, a deluge
of data has become available, as well as standardized data repositories.
Nonetheless, researchers are still facing important challenges in
analyzing the data, especially when considering the complexity of pathways
involved in biological processes or diseases. Data from single sources
seem unable to explain complex processes, such as the ones involved in
brain related disorders, thus rising the need for a more comprehensive
perspective. A possible solution relies on data and model integration,
where several data types are combined to provide complementary views,
which in turn can result in the discovery of previously unknown
biomarkers, by unravelling otherwise hidden relationships between data of
different sources. In this work, we review the different single-source
types of data used for biomarker discovery in neurodegenerative diseases,
and then proceed to provide an overview on recent efforts to perform
integrative analysis in these disorders, discussing major challenges and
Date: 2014-Apr-24 Time: 14:30:00 Room: 336
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Workshop “Metabolism and mathematical models: Two for a tango” – 2nd Edition
Title: Workshop Metabolism and mathematical models: Two for a tango – 2nd Edition
Dates: October 25-26, 2022
Location: This workshop will be held in a virtual way
The topic of this workshop is metabolism in general, with a special focus, although not exclusive, on parasitology. Besides an exploration of the biological, biochemical and biomedical aspects, the workshop will also aim at presenting some of the mathematical modelling, algorithmic theory and software development that have become crucial to explore such aspects.
This workshop is being organised in the context of two projects, both with the Inria European Team Erable. One of the projects involves a partnership with the University of São Paulo (USP), in São Paulo, Brazil, more specifically the Institute of Mathematics and Statistics (IME) and the Institute of Biomedical Sciences – Inria Associated Team Capoeira – and the other involves the Inesc-ID/IST in Portugal, ETH in Zürich and EMBL in Heidelberg – H2020 Twinning Project Olissipo.
The workshop is open to all members of these two projects but also, importantly, to the community in general.
The program and more details are available here.