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- Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning
Zhaoxiang Cai, Sofia Apolinário, Ana Rita Baião, Pacini Clare, Miguel Dinis Madeira Agostinho de Sousa, Susana Vinga, Roger R Reddel, Phillip J Robinson, Mathew J. Garnett, Qing Zhong, Emanuel Gonçalves
Nature Communications
2024 - A comprehensive clinically informed map of dependencies in cancer cells and framework for target prioritization
Pacini Clare, Emma Duncan, Emanuel Gonçalves, James Gilbert, Shriram Bhosle, Stuart Horswell, Emre Karakoc, Howard Lightfoot, Ed Curry, Francesc Muyas, Monsif Bouaboula, Chandra Sekhar Pedamallu, Isidro Cortes-Ciriano, Fiona Behan, Lykourgos-Panagiotis Zalmas, Syd Barthorpe, Hayley E. Francies, Steve Rowley, Jack Pollard, Pedro Beltrão, Leopold Parts, Francesco Iorio, Mathew J. Garnett
Cancer Cell
2024 - Base editing screens map mutations affecting interferon-γ signaling in cancer
Matthew A.Coelho, Sarah Cooper, Magdalena E. Strauss, Emre Karakoc, Shriram Bhosle, Emanuel Gonçalves, Gabriele Picco, Thomas Burgold, Chiara M. Cattaneo, Vivien Veninga, Sarah Consonni, Cansu Dinçer, Sara F. Vieira, Freddy Gibson, Syd Barthorpe, Claire Hardy, Joel Rein, Mark Thomas, John Marioni, Emile E. Voest, Andrew Bassett, Mathew J. Garnett
Cancer Cell DOI https://doi.org/10.1016/j.ccell.2022.12.009
2023 - Pan-cancer proteomic map of 949 human cell lines
Emanuel Gonçalves, Rebecca C Poulos, Zhaoxiang Cai, Syd Barthorpe, Srikanth S Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker, Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G Williams, Yangxiu Wu, Dylan Xavier, Karen L MacKenzie, Peter G Hains, Brett Tully, Phillip J Robinson, Qing Zhong, Mathew J. Garnett, Roger R Reddel
Cancer Cell vol. 40, DOI https://doi.org/10.1016/j.ccell.2022.06.010
2022 - A suspension technique for efficient large-scale cancer organoid culturing and perturbation screens
Stacey Price, Shriram Bhosle, Emanuel Gonçalves, Xiaodun Li, Dylan P. McClurg, Syd Barthorpe, Alex Beck, Caitlin Hall, Howard Lightfoot, Luke Farrow, Rizwan Ansari, David A. Jackson, Laura Allen, Kirsty Roberts, Charlotte Beaver, Hayley E. Francies, Mathew J. Garnett
Scientific Reports vol. 12, DOI https://doi.org/10.1038/s41598-022-09508-y
2022