Inibição da patogénese e construção de fábricas celulares: por desenvolvimento de modelos regulatórios-metabólicos mistos à escala do genoma em leveduras (MIXEDUP)
Type: National Project Project
Duration: from 2018 Oct 01 to 2022 Sep 30
Financed by: FCT
Prime Contractor: R - IST-ID (Other) - Lisboa, Portugal
This project proposes to use Systems Biology approaches and single cell eukaryotes as case studies, in order to design better ways to prevent and control superficial and invasive candidiasis, whose two prime causes are C. albicans and C. glabrata. Genome-scale regulatory models will be built for C. albicans and C. glabrata, using the data gathered at the PathoYeastract database, and the S. cerevisiae regulatory model as a cast (http://yeastract.com). Also, orthology relationships will be considered, extracted from CGD (http://www.candidagenome.org/) and PhylomeDB (http://phylomedb.org/). Finally, a reliable complete genome-scale integrated regulatory-metabolic model will be considered, connecting the metabolic and regulatory models for each of the three yeast species.
Partnerships
- F - Fundação Calouste Gulbenkian (Other) - Lisboa, Portugal
- R - INESC-ID Lisboa (Other) - Lisboa, Portugal
- R - IST-ID (Other) - Lisboa, Portugal
- Universidade do Minho (University) - Braga, Portugal